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[HTML][HTML] Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric …
LD Polit, I Eidhof, RV McNeill, KM Warre-Cornish… - Neuroscience …, 2023 - Elsevier
The number of individuals suffering from neuropsychiatric disorders (NPDs) has increased
worldwide, with 3 million disability-adjusted life-years calculated in 2019. Though research …
worldwide, with 3 million disability-adjusted life-years calculated in 2019. Though research …
[HTML][HTML] Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells
ACM Couch, S Solomon, RRR Duarte… - Brain, Behavior, and …, 2023 - Elsevier
Background Prenatal exposure to elevated interleukin (IL)-6 levels is associated with
increased risk for psychiatric disorders with a putative neurodevelopmental origin, such as …
increased risk for psychiatric disorders with a putative neurodevelopmental origin, such as …
The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases
Long noncoding RNAs (lncRNAs) play multifaceted roles in regulating brain gene networks.
LncRNA abnormalities are thought to underlie the complex etiology of numerous …
LncRNA abnormalities are thought to underlie the complex etiology of numerous …
Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer
H Wang, C Canasto-Chibuque, JH Kim… - Genes & …, 2024 - genesdev.cshlp.org
The MRE11 complex (comprising MRE11, RAD50, and NBS1) is integral to the maintenance
of genome stability. We previously showed that a hypomorphic Mre11 mutant mouse strain …
of genome stability. We previously showed that a hypomorphic Mre11 mutant mouse strain …
[HTML][HTML] Transcriptional and cellular response of hiPSC-derived microglia-neural progenitor co-cultures exposed to IL-6
ACM Couch, AM Brown, C Raimundo… - Brain, Behavior, and …, 2024 - Elsevier
Abstract Elevated interleukin (IL-) 6 levels during prenatal development have been linked to
increased risk for neurodevelopmental disorders (NDD) in the offspring, but the mechanism …
increased risk for neurodevelopmental disorders (NDD) in the offspring, but the mechanism …
[HTML][HTML] Stem-cell derived neurosphere assay highlights the effects of viral infection on human cortical development
E Drydale, P Rath, K Holden, G Holt, L Havins… - Brain, Behavior, and …, 2024 - Elsevier
Aberrant cortical development is a key feature of neurodevelopmental disorders such as
autism spectrum disorder and schizophrenia. Both genetic and environmental risk factors …
autism spectrum disorder and schizophrenia. Both genetic and environmental risk factors …
Harnessing stem cell-based approaches for clinically meaningful discoveries in schizophrenia
Harnessing stem cell-based approaches for clinically meaningful discoveries in
schizophrenia Harnessing stem cell-based approaches for clinically meaningful discoveries …
schizophrenia Harnessing stem cell-based approaches for clinically meaningful discoveries …
Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells
Background Exposure to elevated interleukin (IL)-6 levels in utero is consistently associated
with increased risk for psychiatric disorders with a putative neurodevelopmental origin, such …
with increased risk for psychiatric disorders with a putative neurodevelopmental origin, such …