Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as
ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to …

Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …

Congenital anomalies of the kidney and urinary tract (CAKUT) are a major cause of pediatric
kidney failure. We performed a genome-wide analysis of copy number variants (CNVs) in …

Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and
the glomerular response to injury. A growing body of evidence demonstrates that …

Current kidney organoids model development and diseases of the nephron but not the
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …

Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling
during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by …

The requirement for vitamin A in reproduction was first recognized in the early 1900's, and its
importance in the eyes of develo** embryos was realized shortly after. A greater …

Retinoic acid (RA), the active form of vitamin A, is a small lipophilic molecule that acts as a
signalling molecule in vertebrates by binding to nuclear receptors (heterodimers of RA …

Retinoids comprise a group of compounds each composed of three basic parts: a
trimethylated cyclohexene ring that is a bulky hydrophobic group, a conjugated tetraene side …

The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP)
superfamily members are found in a remarkable range of organisms spanning each of the …