The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …

The interplay between abnormalities in genes coding for proteins and noncoding
microRNAs (miRNAs) has been among the most exciting yet unexpected discoveries in …

A biomarker with high specificity and sensitivity, is a basic requirement for non‐invasive
cancer diagnosis. Exosomes are a type of lipid bilayer extracellular vesicles (EVs) …

In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …

Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized
by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and …

Small, noncoding RNAs are short untranslated RNA molecules, some of which have been
associated with cancer development. Recently we showed that a class of small RNAs …

The mechanisms that drive normal B cell differentiation and activation are frequently
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …

Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte
function. Here, we show that transient inhibition of HNF4α initiates hepatocellular …

In 1984, we investigated the t (14; 18) chromosomal translocations that frequently occur in
patients with follicular lymphoma. We first identified a locus on chromosome 18 involved in …