Neuroinflammation is the coordinated response of the central nervous system (CNS) to
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …

CNS inflammation is a major driver of MS pathology. Differential immune responses,
including the adaptive and the innate immune system, are observed at various stages of MS …

Intravital microscopy (IVM) emerged and matured as a powerful tool for elucidating
pathways in biological processes. Although label-free multiphoton IVM is attractive for its …

Neurodegenerative diseases exert an overwhelming socioeconomic burden all around the
globe. They are mainly characterized by modified protein accumulation that might trigger …

Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

Discussions of multiple sclerosis (MS) pathophysiology tend to focus on T cells and B cells
of the adaptive immune response. The innate immune system is less commonly considered …

Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS)
characterized by an inflammatory process and demyelination. The etiology of the disease is …

Multiple sclerosis (MS) is an autoimmune debilitating disease of the central nervous system
caused by a mosaic of interactions between genetic predisposition and environmental …

Multiple sclerosis (MS) is a neurodegenerative disease associated with inflammatory
demyelination and astroglial activation, with neuronal and axonal damage as the leading …

Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo
calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels …