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Mechanical properties of human tumour tissues and their implications for cancer development
The mechanical properties of cells and tissues help determine their architecture,
composition and function. Alterations to these properties are associated with many diseases …
composition and function. Alterations to these properties are associated with many diseases …
Single-molecule studies of protein folding with optical tweezers
Manipulation of individual molecules with optical tweezers provides a powerful means of
interrogating the structure and folding of proteins. Mechanical force is not only a relevant …
interrogating the structure and folding of proteins. Mechanical force is not only a relevant …
Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape
Statistical mechanics can describe the major conformational ensembles determining the
equilibrium free-energy landscape of a folding protein. The challenge is to capture the full …
equilibrium free-energy landscape of a folding protein. The challenge is to capture the full …
Probing the structural dynamics of proteins and nucleic acids with optical tweezers
Highlights•Optical tweezers provide a sensitive tool to probe structural dynamics.•Native and
non-native folding can be characterized in detail.•Effects of intermolecular interactions on …
non-native folding can be characterized in detail.•Effects of intermolecular interactions on …
Bio-molecular applications of recent developments in optical tweezers
In the past three decades, the ability to optically manipulate biomolecules has spurred a new
era of medical and biophysical research. Optical tweezers (OT) have enabled experimenters …
era of medical and biophysical research. Optical tweezers (OT) have enabled experimenters …
Optical manipulation: advances for biophotonics in the 21st century
Significance: Optical trap** is a technique capable of applying minute forces that has
been applied to studies spanning single molecules up to microorganisms. Aim: The goal of …
been applied to studies spanning single molecules up to microorganisms. Aim: The goal of …
Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape
The timescale for the microscopic dynamics of proteins during conformational transitions is
set by the intrachain diffusion coefficient, D. Despite the central role of protein misfolding and …
set by the intrachain diffusion coefficient, D. Despite the central role of protein misfolding and …
Optical tweezers in single-molecule experiments
In the last decades, optical tweezers have progressively emerged as a unique tool to
investigate the biophysical world, allowing to manipulate and control forces and movements …
investigate the biophysical world, allowing to manipulate and control forces and movements …
Optical tweezers exploring neuroscience
Over the past decade, optical tweezers (OT) have been increasingly used in neuroscience
for studies of molecules and neuronal dynamics, as well as for the study of model organisms …
for studies of molecules and neuronal dynamics, as well as for the study of model organisms …
[HTML][HTML] NCS-1 is a regulator of calcium signaling in health and disease
Abstract Neuronal Calcium Sensor-1 (NCS-1) is a highly conserved calcium binding protein
which contributes to the maintenance of intracellular calcium homeostasis and regulation of …
which contributes to the maintenance of intracellular calcium homeostasis and regulation of …