[HTML][HTML] Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects
Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …
[HTML][HTML] Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression
M Ashrafizadeh, S Mirzaei, MH Gholami… - Carbohydrate …, 2021 - Elsevier
An important motivation for the use of nanomaterials and nanoarchitectures in cancer
therapy emanates from the widespread emergence of drug resistance. Although doxorubicin …
therapy emanates from the widespread emergence of drug resistance. Although doxorubicin …
Dual inhibitors of human DNA topoisomerase II and other cancer-related targets
Human DNA topoisomerase II is an important target in anticancer therapy. Despite the
clinical success of drugs that target topoisomerase II, the development of resistant cancer …
clinical success of drugs that target topoisomerase II, the development of resistant cancer …
[HTML][HTML] Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids
Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …
human diseases including cancer. In this line, now it has become evident that ROS …
Exosome treatment enhances anti-inflammatory M2 macrophages and reduces inflammation-induced pyroptosis in doxorubicin-induced cardiomyopathy
Doxorubicin (Dox) is an effective antineoplastic agent used to treat cancers, but its use is
limited as Dox induces adverse cardiotoxic effects. Dox-induced cardiotoxicity (DIC) can …
limited as Dox induces adverse cardiotoxic effects. Dox-induced cardiotoxicity (DIC) can …
Natural compounds against doxorubicin‐induced cardiotoxicity: a review on the involvement of Nrf2/ARE signaling pathway
Cardiotoxicity is the main concern for long‐term use of the doxorubicin (DOX). Reactive
oxygen species (ROS) generation leads to oxidative stress that significantly contributes to …
oxygen species (ROS) generation leads to oxidative stress that significantly contributes to …
Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review
Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has
strong antioxidative, anti‐inflammatory, and antibacterial properties. Due to these properties …
strong antioxidative, anti‐inflammatory, and antibacterial properties. Due to these properties …
Major obstacles to doxorubicin therapy: Cardiotoxicity and drug resistance
HS Al-Malky, SE Al Harthi… - Journal of Oncology …, 2020 - journals.sagepub.com
Background Doxorubicin is one of the most commonly prescribed and time-tested anticancer
drugs. Although being considered as a first line drug in different types of cancers, the two …
drugs. Although being considered as a first line drug in different types of cancers, the two …
[HTML][HTML] Polychemotherapy with curcumin and doxorubicin via biological nanoplatforms: enhancing antitumor activity
Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …
Drug repurposing in cancer therapy: influence of patient's genetic background in breast cancer treatment
Cancer is among the leading causes of death worldwide and it is estimated that in 2040
more than 29 million people will be diagnosed with some type of cancer. The most prevalent …
more than 29 million people will be diagnosed with some type of cancer. The most prevalent …