Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

M Sadarangani, A Marchant… - Nature Reviews …, 2021 - nature.com
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …

The human genetic epidemiology of COVID-19

MEK Niemi, MJ Daly, A Ganna - Nature Reviews Genetics, 2022 - nature.com
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

Dictionary learning for integrative, multimodal and scalable single-cell analysis

Y Hao, T Stuart, MH Kowalski, S Choudhary… - Nature …, 2024 - nature.com
Map** single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid

C Cervia-Hasler, SC Brüningk, T Hoch, B Fan, G Muzio… - Science, 2024 - science.org
Long Covid is a debilitating condition of unknown etiology. We performed multimodal
proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after …

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

JD Domizio, MF Gulen, F Saidoune, VV Thacker… - Nature, 2022 - nature.com
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung
pathology and extrapulmonary complications,. Type I interferons (IFNs) have an essential …

COVID-19 in people with rheumatic diseases: risks, outcomes, treatment considerations

R Grainger, AHJ Kim, R Conway, J Yazdany… - Nature Reviews …, 2022 - nature.com
The COVID-19 pandemic has brought challenges for people with rheumatic disease in
addition to those faced by the general population, including concerns about higher risks of …

Immune response in COVID-19: what is next?

Q Li, Y Wang, Q Sun, J Knopf, M Herrmann… - Cell Death & …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

Type I and III interferon responses in SARS-CoV-2 infection

YM Kim, EC Shin - Experimental & molecular medicine, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III …

Autoimmune and autoinflammatory connective tissue disorders following COVID-19

SH Lim, HJ Ju, JH Han, JH Lee, WS Lee… - JAMA network …, 2023 - jamanetwork.com
Importance Multiple cases of autoimmune and autoinflammatory diseases after COVID-19
have been reported. However, their incidences and risks have rarely been quantified …

Dermatomyositis with anti-MDA5 antibodies: bioclinical features, pathogenesis and emerging therapies

A Nombel, N Fabien, F Coutant - Frontiers in immunology, 2021 - frontiersin.org
Anti-MDA5 dermatomyositis is a rare systemic autoimmune disease, historically described in
Japanese patients with clinically amyopathic dermatomyositis and life-threatening rapidly …