Protein–protein interactions (PPIs) orchestrate nearly all biological processes. They are also
considered attractive drug targets for treating many human diseases, including cancers and …

Recently, a super uranyl binding protein (SUP) was developed, which exhibits excellent
sensitivity/selectivity to bind uranyl ions. It can be immobilized onto a surface in sensing …

New protein-fragment complementation assays (PCA) have successfully been developed to
characterize protein–protein interactions in vitro and in vivo. Notably, the NanoBiT …

Staphylococcus aureus is a common human commensal pathogen that causes a wide range
of infectious diseases. Due to the generation of antimicrobial resistance, the pathogen …

PII proteins constitute a widespread signal transduction superfamily in the prokaryotic world.
The canonical PII signal proteins sense metabolic state of the cells by binding the metabolite …

Formation of a bacterial RNA polymerase (RNAP) holoenzyme by a catalytic core RNAP and
a sigma (σ) initiation factor is essential for bacterial viability. As the primary binding site for …

Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent,
accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We …

RNA polymerase is an essential enzyme involved in bacterial transcription, playing a crucial
role in RNA synthesis. However, it requires the association with sigma factors to initiate this …

Transcription is an essential biological process in bacteria requiring a core enzyme, RNA
polymerase (RNAP). Bacterial RNAP is catalytically active but requires sigma (σ) factors for …

Discovery of antibiotics of a novel mode of action is highly required in the fierce battlefield
with multi-drug resistant bacterial infections. Previously we have validated the protein …