The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …

Autonomous regulation of the intestine requires the combined activity of functionally distinct
neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types …

Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …

Cortical interneurons display striking differences in shape, physiology, and other attributes,
challenging us to appropriately classify them. We previously suggested that interneuron …

Cells of the spinal cord and somites arise from shared, dual-fated precursors, located
towards the posterior of the elongating embryo. Here we show that these neuromesodermal …

The generation of induced pluripotent stem cells (iPSCs) and induced neuronal cells (iNCs)
from somatic cells provides new avenues for basic research and potential transplantation …

The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …

Various studies have demonstrated that somatic differentiated cells can be reprogrammed
into other differentiated states or into pluripotency, thus showing that the differentiated …

Distinct midbrain dopamine (mDA) neuron subtypes are found in the substantia nigra pars
compacta (SNc) and the ventral tegmental area (VTA), but it is mainly SNc neurons that …