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Organization and regulation of gene transcription
The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
[HTML][HTML] Loo** back to leap forward: transcription enters a new era
Comparative genome analyses reveal that organismal complexity scales not with gene
number but with gene regulation. Recent efforts indicate that the human genome likely …
number but with gene regulation. Recent efforts indicate that the human genome likely …
PLIP 2021: expanding the scope of the protein–ligand interaction profiler to DNA and RNA
With the growth of protein structure data, the analysis of molecular interactions between
ligands and their target molecules is gaining importance. PLIP, the protein–ligand …
ligands and their target molecules is gaining importance. PLIP, the protein–ligand …
Structure of paused transcription complex Pol II–DSIF–NELF
Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the
promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB …
promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB …
Structural basis of R-loop recognition by the S9. 6 monoclonal antibody
R-loops are ubiquitous, dynamic nucleic-acid structures that play fundamental roles in DNA
replication and repair, chromatin and transcription regulation, as well as telomere …
replication and repair, chromatin and transcription regulation, as well as telomere …
Near-atomic resolution visualization of human transcription promoter opening
In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that
assembles at the core promoter is required for the opening of the duplex DNA and …
assembles at the core promoter is required for the opening of the duplex DNA and …
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide
Covering: 1992 up to 2023 Since their discovery, lasso peptides went from peculiarities to
be recognized as a major family of ribosomally synthesized and post-translationally modified …
be recognized as a major family of ribosomally synthesized and post-translationally modified …
Structural basis for the initiation of eukaryotic transcription-coupled DNA repair
Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-
pathway of nucleotide excision repair that preferentially removes DNA lesions from the …
pathway of nucleotide excision repair that preferentially removes DNA lesions from the …
Structural biology of RNA polymerase II transcription: 20 years on
Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …
eukaryotic genome and a focal point for cellular regulation during development …
Inhibition of transcription by platinum antitumor compounds
RC Todd, SJ Lippard - Metallomics, 2009 - academic.oup.com
Cisplatin, carboplatin, and oxaliplatin are three FDA-approved members of the platinum
anticancer drug family. These compounds induce apoptosis in tumor cells by binding to …
anticancer drug family. These compounds induce apoptosis in tumor cells by binding to …