Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

Diabetic nephropathy is characterized by damage to both the glomerulus and
tubulointerstitium, but relatively little is known about accompanying cell-specific changes in …

Dependence receptors (DRs) now form a family of more than a dozen membrane receptors
that are not linked by their structure, but by common functional traits. The most notable is …

Fragile X syndrome (FXS) is an inherited neurologic disease caused by loss of fragile X
mental retardation protein (FMRP), which is hypothesized to mediate negative regulation of …

Robo4 is an endothelial cell-specific member of the Roundabout axon guidance receptor
family. To identify Robo4 binding partners, we performed a protein-protein interaction screen …

Abstract The netrin‐1/DCC ligand/receptor pair has key roles in central nervous system
(CNS) development, mediating axonal, and neuronal navigation. Although expression of …

The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-
1, and this is important for neuronal and vascular development and for limitation of cancer …

Axon-guidance-pathway molecules are involved in connectivity and repair throughout life
(beyond guiding brain wiring during fetal development). One study found that variations …

As a classic immunoregulatory and anti-inflammatory cytokine, interleukin-10 (IL-10)
provides neuroprotection in cerebral ischemia in vivo or oxygen-glucose deprivation (OGD) …

Netrin-1, a family member of laminin-related secreted proteins, mediates axon guidance and
cell migration during neural development. T835M mutation in netrin receptor UNC5C …