Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology
guided by real-time imaging. Using focused ultrasound delivered from outside the body …
guided by real-time imaging. Using focused ultrasound delivered from outside the body …
[HTML][HTML] For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy
Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …
First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study
J Vidal-Jove, X Serres, E Vlaisavljevich… - International Journal …, 2022 - Taylor & Francis
Rationale Current hepatic locoregional therapies are limited in terms of effectiveness and
toxicities. Given promising pre-clinical results, a first in-human trial was designed to assess …
toxicities. Given promising pre-clinical results, a first in-human trial was designed to assess …
Immunomodulation and targeted drug delivery with high intensity focused ultrasound (HIFU): Principles and mechanisms
H Ashar, A Ranjan - Pharmacology & Therapeutics, 2023 - Elsevier
High intensity focused ultrasound (HIFU) is a non-invasive and non-ionizing sonic energy-
based therapeutic technology for inducing thermal and non-thermal effects in tissues …
based therapeutic technology for inducing thermal and non-thermal effects in tissues …
Histotripsy: a method for mechanical tissue ablation with ultrasound
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …
The histotripsy spectrum: differences and similarities in techniques and instrumentation
Since its inception about two decades ago, histotripsy–a non-thermal mechanical tissue
ablation technique–has evolved into a spectrum of methods, each with distinct potentiating …
ablation technique–has evolved into a spectrum of methods, each with distinct potentiating …
Immunological effects of histotripsy for cancer therapy
A Hendricks-Wenger, R Hutchison… - Frontiers in …, 2021 - frontiersin.org
Cancer is the second leading cause of death worldwide despite major advancements in
diagnosis and therapy over the past century. One of the most debilitating aspects of cancer …
diagnosis and therapy over the past century. One of the most debilitating aspects of cancer …
Measurement of ex vivo liver, brain and pancreas thermal properties as function of temperature
The ability to predict heat transfer during hyperthermal and ablative techniques for cancer
treatment relies on understanding the thermal properties of biological tissue. In this work, the …
treatment relies on understanding the thermal properties of biological tissue. In this work, the …
Magic bubbles: utilizing histotripsy to modulate the tumor microenvironment and improve systemic anti-tumor immune responses
Focused Ultrasound (FUS) is emerging as a promising primary and adjunct therapy for the
treatment of cancer. This includes histotripsy, which is a noninvasive, non-ionizing, non …
treatment of cancer. This includes histotripsy, which is a noninvasive, non-ionizing, non …
Transcranial histotripsy parameter study in primary and metastatic murine brain tumor models
Objective This study investigated the effect of various histotripsy dosages on tumor cell kill
and associated bleeding in two murine brain tumor models (glioma [Gl261] and lung …
and associated bleeding in two murine brain tumor models (glioma [Gl261] and lung …