Melatonin as an antioxidant: under promises but over delivers

RJ Reiter, JC Mayo, DX Tan, RM Sainz… - Journal of pineal …, 2016 - Wiley Online Library
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas

RJ Reiter, S Rosales-Corral, DX Tan, MJ Jou… - Cellular and molecular …, 2017 - Springer
Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been
retained throughout evolution such that it may be or may have been present in every species …

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

LC Manchester, A Coto‐Montes, JA Boga… - Journal of pineal …, 2015 - Wiley Online Library
Melatonin is remarkably functionally diverse with actions as a free radical scavenger and
antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule …

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Melatonin: a mitochondrial targeting molecule involving mitochondrial protection and dynamics

DX Tan, LC Manchester, L Qin, RJ Reiter - International journal of …, 2016 - mdpi.com
Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation
is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N …

Roles of melatonin in abiotic stress resistance in plants

N Zhang, Q Sun, H Zhang, Y Cao… - Journal of …, 2015 - academic.oup.com
In recent years melatonin has emerged as a research highlight in plant studies. Melatonin
has different functions in many aspects of plant growth and development. The most …

Melatonin: a versatile protector against oxidative DNA damage

A Galano, DX Tan, RJ Reiter - Molecules, 2018 - mdpi.com
Oxidative damage to DNA has important implications for human health and has been
identified as a key factor in the onset and development of numerous diseases. Thus, it is …

Melatonin: A mitochondrial resident with a diverse skill set

RJ Reiter, R Sharma, S Rosales-Corral… - Life Sciences, 2022 - Elsevier
Melatonin is an ancient molecule that originated in bacteria. When these prokaryotes were
phagocytized by early eukaryotes, they eventually developed into mitochondria and …

[Retracted] Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems

B Sharma, S Singh, NJ Siddiqi - BioMed research international, 2014 - Wiley Online Library
Several workers have extensively worked out the metal induced toxicity and have reported
the toxic and carcinogenic effects of metals in human and animals. It is well known that these …

Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …