Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the
genus Leishmania. The clinical manifestation of the disease varies from self-limiting …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

The kinetoplastids Trypanosoma brucei and Leishmania mexicana are eukaryotes with a
highly structured cellular organisation that is reproduced with great fidelity in each …

G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene
expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast …

A number of medically important microbial pathogens target and proliferate within
macrophages and other phagocytic cells in their mammalian hosts. While the majority of …

Parasitic protozoa, such as malaria parasites, trypanosomes, and Leishmania, acquire a
plethora of nutrients from their hosts, employing transport proteins located in the plasma …

The loss of key biosynthetic pathways is a common feature of important parasitic protists,
making them heavily dependent on scavenging nutrients from their hosts. This is often …

Intracellular parasites, such as Leishmania spp, must acquire suitable carbon sources from
the host cell in order to replicate. Here we present evidence that intracellular amastigote …

Leishmaniasis is a neglected tropical disease caused by Leishmania parasites and is
associated to more than 1.3 million cases annually. Some of the pharmacological options for …

Leishmania spp. are sandfly-transmitted protozoa parasites that cause a spectrum of
diseases in humans. Many enzymes involved in Leishmania central carbon metabolism …