Single-molecule localization microscopy
Single-molecule localization microscopy (SMLM) describes a family of powerful imaging
techniques that dramatically improve spatial resolution over standard, diffraction-limited …
techniques that dramatically improve spatial resolution over standard, diffraction-limited …
Technological advances in super-resolution microscopy to study cellular processes
Since its initial demonstration in 2000, far-field super-resolution light microscopy has
undergone tremendous technological developments. In parallel, these developments have …
undergone tremendous technological developments. In parallel, these developments have …
Structural progression of Alzheimer's disease over decades: The MRI staging scheme
The chronological progression of brain atrophy over decades, from pre-symptomatic to
dementia stages, has never been formally depicted in Alzheimer's disease. This is mainly …
dementia stages, has never been formally depicted in Alzheimer's disease. This is mainly …
[HTML][HTML] Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
Tau is a soluble protein interacting with tubulin to stabilize microtubules. However, under
pathological conditions, it becomes hyperphosphorylated and aggregates, a process that …
pathological conditions, it becomes hyperphosphorylated and aggregates, a process that …
Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles
Neuronal communication relies on the release of neurotransmitters from various populations
of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities …
of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities …
Lung endothelium, tau, and amyloids in health and disease
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer's disease and related tauopathies
Highlights•Dementia involves the chronic and progressive deterioration of cognitive
functions.•Alzheimer's disease is the most common form of dementia.•Abnormally …
functions.•Alzheimer's disease is the most common form of dementia.•Abnormally …
Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission
SM Coscia, CP Thompson, Q Tang… - Journal of Cell …, 2023 - journals.biologists.com
Mitochondrial homeostasis requires a dynamic balance of fission and fusion. The actin
cytoskeleton promotes fission, and we found that the mitochondrially localized myosin …
cytoskeleton promotes fission, and we found that the mitochondrially localized myosin …
ECLiPSE: a versatile classification technique for structural and morphological analysis of 2D and 3D single-molecule localization microscopy data
Single-molecule localization microscopy (SMLM) has gained widespread use for visualizing
the morphology of subcellular organelles and structures with nanoscale spatial resolution …
the morphology of subcellular organelles and structures with nanoscale spatial resolution …
Discovery of novel acridane-based tubulin polymerization inhibitors with anticancer and potential immunomodulatory effects
X Peng, Y Ren, W Pan, J Liu… - Journal of medicinal …, 2022 - ACS Publications
A series of novel acridane-based tubulin polymerization inhibitors were designed,
synthesized, and bioevaluated as anticancer agents. The most potent compound NT-6 …
synthesized, and bioevaluated as anticancer agents. The most potent compound NT-6 …