Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …

Catalytic transformation of ubiquitous C–H bonds into valuable C–N bonds offers an efficient
synthetic approach to construct N-functionalized molecules. Over the last few decades …

Late-stage diversification of natural products is an efficient way to generate natural product
derivatives for drug discovery and chemical biology. Benefiting from the development of site …

The atomistic change of C (sp3)–H to C (sp3)–O can have a profound impact on the physical
and biological properties of small molecules. Traditionally, chemical synthesis has relied on …

Hydrogenations constitute fundamental processes in organic chemistry and allow for atom-
efficient and clean functional group transformations. In fact, the selective reduction of nitriles …

Manganese is found in the active center of numerous enzymes that operate by an outer-
sphere homolytic C–H cleavage. Thus, a plethora of bioinspired radical-based C–H …