Conformational changes underpin function and encode complex biomolecular mechanisms.
Gaining atomic-level detail of how such changes occur has the potential to reveal these …

Augur is a trustless, decentralized platform for prediction markets. It is an extension of Bitcoin
Core's source code which preserves as much of Bitcoin's proven code and security as …

Gene expression models, which are key towards understanding cellular regulatory
response, underlie observations of single-cell transcriptional dynamics. Although RNA …

The generalized master equation (GME) provides a powerful approach to study
biomolecular dynamics via non-Markovian dynamic models built from molecular dynamics …

We present a unified conceptual framework and the associated software package for single-
molecule Förster resonance energy transfer (smFRET) analysis from single-photon arrivals …

Here we adapt the Bayesian nonparametrics (BNP) framework presented in the first
companion article to analyze kinetics from single-photon, single-molecule Förster resonance …

Conformational memory in single-molecule dynamics has attracted recent attention and, in
particular, has been invoked as a possible explanation of some of the intriguing properties of …

Protein conformational changes play crucial roles in their biological functions. In recent
years, the Markov State Model (MSM) constructed from extensive Molecular Dynamics (MD) …

Summary Hidden Markov models (HMMs) are used to learn single-molecule kinetics across
a range of experimental techniques. By their construction, HMMs assume that single …

Whether single-molecule trajectories, observed experimentally or in molecular simulations,
can be described using simple models such as biased diffusion is a subject of considerable …