The intricate role of CXCR4 in cancer
Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
Assessing the interactions between radiotherapy and antitumour immunity
Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has
transformed the treatment of cancer, enabling long-term tumour control even in individuals …
transformed the treatment of cancer, enabling long-term tumour control even in individuals …
Imaging of CXC motif chemokine receptor 4 expression in 690 patients with solid or hematologic neoplasms using 68Ga-pentixafor PET
In recent years, molecular imaging addressing the CXC motif chemokine receptor 4
(CXCR4) has increasingly been used in various clinical settings. Here, we aimed to assess …
(CXCR4) has increasingly been used in various clinical settings. Here, we aimed to assess …
CXCR4-directed theranostics in oncology and inflammation
Given its prominent role in inflammation and cancer biology, the CXC motif chemokine
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …
Human cancer cell membrane-coated biomimetic nanoparticles reduce fibroblast-mediated invasion and metastasis and induce T-cells
Biomimetic nanoparticles (NPs) combine the flexibility and reproducibility of synthetic
materials with the functionality of biological materials. Here, we developed and …
materials with the functionality of biological materials. Here, we developed and …
In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma
K Philipp‐Abbrederis, K Herrmann, S Knop… - EMBO molecular …, 2015 - embopress.org
CXCR 4 is a G‐protein‐coupled receptor that mediates recruitment of blood cells toward its
ligand SDF‐1. In cancer, high CXCR 4 expression is frequently associated with tumor …
ligand SDF‐1. In cancer, high CXCR 4 expression is frequently associated with tumor …
[HTML][HTML] Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging
Chemokine ligand-receptor interactions play a pivotal role in cell attraction and cellular
trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor …
trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor …
Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential
Background Tumour acidosis is considered to play a central role in promoting cancer
invasion and migration, but few studies have investigated in vivo how tumour pH correlates …
invasion and migration, but few studies have investigated in vivo how tumour pH correlates …
PET of CXCR4 expression by a 68Ga-labeled highly specific targeted contrast agent
E Gourni, O Demmer, M Schottelius… - Journal of Nuclear …, 2011 - Soc Nuclear Med
The overexpression of the chemokine receptor CXCR4 plays an important role in oncology,
since together with its endogenous ligand, the stromal cell–derived factor (SDF1-α), CXCR4 …
since together with its endogenous ligand, the stromal cell–derived factor (SDF1-α), CXCR4 …
The immunoimaging toolbox
The recent clinical success of cancer immunotherapy has renewed interest in the
development of tools to image the immune system. In general, immunotherapies attempt to …
development of tools to image the immune system. In general, immunotherapies attempt to …