Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Importance After decades of decline, the US cardiovascular disease mortality rate flattened
after 2010, and racial and ethnic differences in cardiovascular disease mortality persisted …

Hypertension is the leading cause of cardiovascular disease and premature death
worldwide. Owing to the widespread use of antihypertensive medications, global mean …

In 2009, China launched a major health-care reform and pledged to provide all citizens with
equal access to basic health care with reasonable quality and financial risk protection. The …

Importance Racial and ethnic groups with higher rates of clinical Alzheimer disease (AD) are
underrepresented in studies of AD biomarkers, including amyloid positron emission …

Hypertension is a global public health problem, and its prevalence is increasing worldwide.
Impacting all human societies and socioeconomic strata, it remains the major modifiable risk …

After decades of robust growth, the rise in US life expectancy stalled after 2010.
Explanations for the stall have focused on rising drug-related deaths. Here we show that a …

Importance Adherence to a healthy lifestyle is associated with lower risks of adverse
outcomes. However, trends in multiple lifestyle factors and overall healthy lifestyle status …

Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting
delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a …