Maternal embryonic leucine zipper kinase in tumor cells and tumor microenvironment: An emerging player and promising therapeutic opportunity

BF Tang, RC Yan, SW Wang, ZC Zeng, SS Du - Cancer Letters, 2023 - Elsevier
Maternal embryonic leucine zipper kinase (MELK) is a member of the AMPK (AMP-activated
protein kinase) protein family, which is widely and highly expressed in multiple cancer types …

KLF5-induced BBOX1-AS1 contributes to cell malignant phenotypes in non-small cell lung cancer via sponging miR-27a-5p to up-regulate MELK and activate FAK …

J Shi, C Yang, J An, D Hao, C Liu, J Liu, J Sun… - Journal of Experimental …, 2021 - Springer
Background Non-small cell lung cancer (NSCLC) is a major histological subtype of lung
cancer with high mortality and morbidity. A substantial amount of evidence demonstrates …

xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade

B Tang, J Zhu, F Liu, J Ding, Y Wang, S Fang… - Cell Death & …, 2022 - nature.com
Colorectal cancer (CRC) is one of the most commonly diagnosed and deadly malignant
tumors globally, and its occurrence and progression are closely related to the poor …

PCAT19: the role in cancer pathogenesis and beyond

H Hu, H Luo, Z Deng - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
PCAT19, a long non-coding RNA, has attracted considerable attention due to its diverse
roles in various malignancies. This work compiles current research on PCAT19's …

MammaPrint and BluePrint comprehensively capture the cancer hallmarks in early‐stage breast cancer patients

JC Haan, R Bhaskaran, A Ellappalayam… - Genes …, 2022 - Wiley Online Library
MammaPrint®(MP) is a 70‐gene signature that stratifies early‐stage breast cancer patients
into low‐and high risk of distant relapse. Further stratification of MP risk results identifies four …

[HTML][HTML] Recapitulation of patient-specific 3D chromatin conformation using machine learning

D Xu, AN Forbes, S Cohen, A Palladino… - Cell reports …, 2023 - cell.com
Regulatory networks containing enhancer-gene edges define cellular states. Multiple efforts
have revealed these networks for reference tissues and cell lines by integrating multi-omics …

Identification of early diagnostic biomarkers for breast cancer through bioinformatics analysis

S Yan, S Yue - Medicine, 2023 - journals.lww.com
In the realm of clinical practice, there is currently an insufficiency of distinct biomarkers
available for the detection of breast cancer. It is of utmost importance to promptly employ …

Integrated analysis of the roles of oxidative stress related genes and prognostic value in clear cell renal cell carcinoma

D Wang, Z Deng, M Lu, K Deng, Z Li, F Zhou - Journal of Cancer Research …, 2023 - Springer
Background Patients with clear cell renal cell carcinoma (ccRCC), which is the most
commonly diagnosed subtype of renal cell carcinoma, are at risk of tumor metastasis and …

[HTML][HTML] MAPKAPK2-centric transcriptome profiling reveals its major role in governing molecular crosstalk of IGFBP2, MUC4, and PRKAR2B during HNSCC …

S Soni, P Anand, MK Swarnkar, V Patial… - Computational and …, 2023 - Elsevier
Transcriptome analysis of head and neck squamous cell carcinoma (HNSCC) has been
pivotal to comprehending the convoluted biology of HNSCC tumors. MAPKAPK2 or MK2 is a …

[PDF][PDF] Icariin induces apoptosis in breast cancer MCF-7 cells by regulating the MELK mediated PI3K/AKT signaling pathway

D Qian, Y Zhu, L Xu, T Dong, T Chen… - Eur J Gynaecol …, 2021 - article.imrpress.com
Objective: To investigate the mechanism of icariin in promoting apoptosis of breast cancer
cells by regulating the Phosphatidylinositol kinase (PI3K) PI3K/AKT signaling pathway …