Stereodynamic strategies to induce and enrich chirality of atropisomers at a late stage

CB Roos, CH Chiang, LAM Murray, D Yang… - Chemical …, 2023‏ - ACS Publications
Enantiomers, where chirality arises from restricted rotation around a single bond, are
atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to …

Asymmetric catalysis mediated by synthetic peptides, version 2.0: expansion of scope and mechanisms

AJ Metrano, AJ Chinn, CR Shugrue, EA Stone… - Chemical …, 2020‏ - ACS Publications
Low molecular weight synthetic peptides have been demonstrated to be effective catalysts
for an increasingly wide array of asymmetric transformations. In many cases, these peptide …

Peptide-based catalysts reach the outer sphere through remote desymmetrization and atroposelectivity

AJ Metrano, SJ Miller - Accounts of Chemical Research, 2018‏ - ACS Publications
Conspectus Nature's catalytic machinery has provided endless inspiration for chemists.
While the enzymatic ideal has yet to be fully realized, the field has made tremendous strides …

[HTML][HTML] Application of FTIR method for the assessment of immobilization of active substances in the matrix of biomedical materials

D Kowalczuk, M Pitucha - Materials, 2019‏ - mdpi.com
Background: The purpose of the study was to demonstrate the usefulness of the Fourier
transform infrared spectroscopy (FTIR) method for the evaluation of the modification process …

Cryogenic ion chemistry and spectroscopy

AB Wolk, CM Leavitt, E Garand… - Accounts of Chemical …, 2014‏ - ACS Publications
The use of mass spectrometry in macromolecular analysis is an incredibly important
technique and has allowed efficient identification of secondary and tertiary protein …

Hydrogen-bonding effects on infrared spectra from anharmonic computations: uracil–water complexes and uracil dimers

T Fornaro, D Burini, M Biczysko… - The Journal of physical …, 2015‏ - ACS Publications
Hydrogen-bonding interactions lead to significant changes in the infrared (IR) spectrum, like
frequency shifts of the order of magnitude of hundreds of cm–1 and increases of IR intensity …

Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed Atroposelective Bromination

ME Diener, AJ Metrano, S Kusano… - Journal of the American …, 2015‏ - ACS Publications
We report the development of a tertiary amine-containing β-turn peptide that catalyzes the
atroposelective bromination of pharmaceutically relevant 3-arylquinazolin-4 (3 H)-ones …

Helium tagging infrared photodissociation spectroscopy of reactive ions

J Roithová, A Gray, E Andris, J Jasik… - Accounts of Chemical …, 2016‏ - ACS Publications
Conspectus The interrogation of reaction intermediates is key for understanding chemical
reactions; however their direct observation and study remains a considerable challenge …

Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones

YB Wang, SC Zheng, YM Hu, B Tan - Nature Communications, 2017‏ - nature.com
The axially chiral arylquinazolinone acts as a privileged structural scaffold, which is present
in a large number of natural products and biologically active compounds as well as in chiral …

From solution to the gas phase: stepwise dehydration and kinetic trap** of substance P reveals the origin of peptide conformations

JA Silveira, KL Fort, DY Kim, KA Servage… - Journal of the …, 2013‏ - ACS Publications
Past experimental results and molecular dynamics simulations provide evidence that, under
some conditions, electrospray ionization (ESI) of biomolecules produces ions that retain …