The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Fueled by developments in computational neuroscience, there has been increasing interest
in the underlying neurocomputational mechanisms of psychosis. One successful approach …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

Hallucinations, perceptions in the absence of objectively identifiable stimuli, illustrate the
constructive nature of perception. Here, we highlight the role of prior beliefs as a critical …

INTRODUCTION Psychotic disorders such as schizophrenia impose enormous human,
social, and economic burdens. The prognosis of psychotic disorders has not substantially …

Many theories of brain function propose that activity in sparse subsets of neurons underlies
perception and action. To place a lower bound on the amount of neural activity that can be …

The idea that predictions shape how we perceive and comprehend the world has become
increasingly influential in the field of systems neuroscience. It also forms an important …

The aberrant salience hypothesis proposes that striatal dopamine dysregulation causes
misattribution of salience to irrelevant stimuli leading to psychosis. Recently, new lines of …

Hearing a voice in the absence of any speaker can be a significant feature of psychiatric
illness, but is also increasingly acknowledged as an important aspect of everyday, non …