Insects possess an immune system that protects them from attacks by various pathogenic
microorganisms that would otherwise threaten their survival. Immune mechanisms may deal …

The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …

Many innate immune mechanisms are conserved throughout the animal kingdom. Manduca
sexta, a widely used model for insect biochemical research, employs these mechanisms to …

Abstract The neonatal Fc receptor (FcRn) transports immunoglobulin G (IgG) across
epithelia, binding IgG in acidic vesicles (pH≤ 6.5) and releasing IgG in the blood at pH 7.4 …

Lepidopteran insects provide important model systems for innate immunity of insects,
particularly for cell biology of hemocytes and biochemical analyses of plasma proteins …

Summary Stem Cell Factor (SCF) initiates its multiple cellular responses by binding to the
ectodomain of KIT, resulting in tyrosine kinase activation. We describe the crystal structure of …

Recent genomic analysis has shown that proteins with immunoglobulin superfamily (IgSF)
domains are extremely abundant and their number has increased markedly in evolution …

The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor
involved in inflammatory processes and is associated with diabetic complications, tumor …

Abstract Immunoglobulin-α (IgA)-bound antigens induce immune effector responses by
activating the IgA-specific receptor FcαRI (CD89) on immune cells. Here we present crystal …

Type I and II classical cadherins help to determine the adhesive specificities of animal cells.
Crystal-structure determination of ectodomain regions from three type II cadherins reveals …