[HTML][HTML] NTM drug discovery: status, gaps and the way forward
Highlights•Incidence of lung disease caused by non-TB mycobacteria (NTM) is
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …
The challenge of new drug discovery for tuberculosis
Tuberculosis (TB) is more prevalent in the world today than at any other time in human
history. Mycobacterium tuberculosis, the pathogen responsible for TB, uses diverse …
history. Mycobacterium tuberculosis, the pathogen responsible for TB, uses diverse …
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
New therapeutic strategies are needed to combat the tuberculosis pandemic and the spread
of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease …
of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease …
Biology of antimicrobial resistance and approaches to combat it
Insufficient development of new antibiotics and the rising resistance of bacteria to those that
we have are putting the world at risk of losing the most widely curative class of medicines …
we have are putting the world at risk of losing the most widely curative class of medicines …
Defining the core essential genome of Pseudomonas aeruginosa
Genomics offered the promise of transforming antibiotic discovery by revealing many new
essential genes as good targets, but the results fell short of the promise. While numerous …
essential genes as good targets, but the results fell short of the promise. While numerous …
Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium's Metabolism Is Constrained by the Intracellular Environment
BC VanderVen, RJ Fahey, W Lee, Y Liu… - PLoS …, 2015 - journals.plos.org
Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to
support growth in macrophages. By conducting an extensive, unbiased chemical screen to …
support growth in macrophages. By conducting an extensive, unbiased chemical screen to …
Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism
Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment
of multidrug-resistant tuberculosis in decades. Though BDQ has shown excellent efficacy in …
of multidrug-resistant tuberculosis in decades. Though BDQ has shown excellent efficacy in …
Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection
The recent discovery of small molecules targeting the cytochrome bc 1: aa 3 in
Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for …
Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for …
Environmental and genetic modulation of the phenotypic expression of antibiotic resistance
Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …
and generally an acquired mechanism results in a predictable increase in phenotypic …
Metabolic regulation of antibiotic resistance
It is generally assumed that antibiotics and resistance determinants are the task forces of a
biological warfare in which each resistance determinant counteracts the activity of a specific …
biological warfare in which each resistance determinant counteracts the activity of a specific …