[HTML][HTML] Biomechanics of the human intervertebral disc: a review of testing techniques and results

N Newell, JP Little, A Christou, MA Adams… - Journal of the …, 2017 - Elsevier
Many experimental testing techniques have been adopted in order to provide an
understanding of the biomechanics of the human intervertebral disc (IVD). The aim of this …

Meniscus, articular cartilage and nucleus pulposus: a comparative review of cartilage-like tissues in anatomy, development and function

S Chen, P Fu, H Wu, M Pei - Cell and tissue research, 2017 - Springer
The degradation of cartilage in the human body is impacted by aging, disease, genetic
predisposition and continued insults resulting from daily activity. The burden of cartilage …

Materials for the spine: anatomy, problems, and solutions

BA Frost, S Camarero-Espinosa, EJ Foster - Materials, 2019 - mdpi.com
Disc degeneration affects 12% to 35% of a given population, based on genetics, age,
gender, and other environmental factors, and usually occurs in the lumbar spine due to …

Mechanobiology of annulus fibrosus and nucleus pulposus cells in intervertebral discs

S Molladavoodi, J McMorran, D Gregory - Cell and Tissue Research, 2020 - Springer
Low back pain (LBP) is a chronic condition that can affect up to 80% of the global
population. It is the number one cause of disability worldwide and has enormous …

[HTML][HTML] Challenges and strategies in the repair of ruptured annulus fibrosus

CC Guterl, EY See, SBG Blanquer… - European cells & …, 2013 - ncbi.nlm.nih.gov
Lumbar discectomy is the surgical procedure most frequently performed for patients
suffering from low back pain and sciatica. Disc herniation as a consequence of degenerative …

Mechanotransduction and cell biomechanics of the intervertebral disc

BV Fearing, PA Hernandez, LA Setton… - JOR spine, 2018 - Wiley Online Library
Mechanical loading of the intervertebral disc (IVD) initiates cell‐mediated remodeling events
that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus …

Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges

JL Bron, MN Helder, HJ Meisel, BJ Van Royen… - European spine …, 2009 - Springer
Lumbar discectomy is a very effective therapy for neurological decompression in patients
suffering from sciatica due to hernia nuclei pulposus. However, high recurrence rates and …

Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc

SS Sivan, AJ Hayes, E Wachtel, B Caterson… - European Spine …, 2014 - Springer
Background The intervertebral disc (IVD) is a complex cartilaginous structure which
functions to resist biomechanical loads during spinal movement. It consists of the highly …

The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells

C Liu, C Zhu, J Li, P Zhou, M Chen, H Yang, B Li - Bone research, 2015 - nature.com
Annulus fibrosus (AF) tissue engineering has recently received increasing attention as a
treatment for intervertebral disc (IVD) degeneration; however, such engineering remains …

Extracellular matrix in intervertebral disc: basic and translational implications

S Zhang, W Liu, S Chen, B Wang, P Wang, B Hu… - Cell and Tissue …, 2022 - Springer
Intervertebral disc (IVD) degeneration (IVDD) is the most common spinal disorder, which can
lead to the symptoms of neck pain or low back pain. In healthy mature IVD tissues …