Intrinsically disordered proteins in cellular signalling and regulation
PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …
machinery, allowing the same polypeptide to undertake different interactions with different …
Classification of intrinsically disordered regions and proteins
Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …
Molecular dynamics simulations in drug discovery and pharmaceutical development
Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …
development process. In this review, we give a broad overview of the current application …
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
INTRODUCTION Sensing of pathogenic microbes and tissue damage by the innate immune
system triggers immune cells to secrete cytokines that promote host defense. Viral RNA …
system triggers immune cells to secrete cytokines that promote host defense. Viral RNA …
Stress-triggered phase separation is an adaptive, evolutionarily tuned response
In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress
granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels …
granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels …
Intrinsically disordered proteins and their “mysterious”(meta) physics
VN Uversky - Frontiers in Physics, 2019 - frontiersin.org
Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …
Continuous distributed representation of biological sequences for deep proteomics and genomics
We introduce a new representation and feature extraction method for biological sequences.
Named bio-vectors (BioVec) to refer to biological sequences in general with protein-vectors …
Named bio-vectors (BioVec) to refer to biological sequences in general with protein-vectors …
Intrinsically disordered proteins and intrinsically disordered protein regions
Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …
DISOPRED3: precise disordered region predictions with annotated protein-binding activity
Motivation: A sizeable fraction of eukaryotic proteins contain intrinsically disordered regions
(IDRs), which act in unfolded states or by undergoing transitions between structured and …
(IDRs), which act in unfolded states or by undergoing transitions between structured and …
Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues
RK Das, RV Pappu - … of the National Academy of Sciences, 2013 - National Acad Sciences
The functions of intrinsically disordered proteins (IDPs) are governed by relationships
between information encoded in their amino acid sequences and the ensembles of …
between information encoded in their amino acid sequences and the ensembles of …