Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …

Transcription factors with aberrant activity in disease are promising yet untested targets for
therapeutic development, particularly in oncology. Directly inhibiting or activating the …

The transcription factor Max is a basic-helix-loop-helix leucine zipper (bHLHLZ) protein that
forms homodimers or interacts with other bHLHLZ proteins, including Myc and Mxd proteins …

Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …

Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation
therapies but frequently remain dependent on oncogenic transcription driven by the …

Drug discovery is a sophisticated process that incorporates scientific innovations and cutting-
edge technologies. Compared to traditional bioactivity-based screening methods, encoding …

We previously described a mouse model of ulcerative colitis linked to T-bet deficiency in the
innate immune system. Here, we report that the majority of T-bet−/− RAG2−/− ulcerative …

Non-coding RNAs (ncRNAs) have been defined as a class of RNA molecules transcribed
from the genome but not encoding proteins, such as microRNAs, long non-coding RNAs …

Identification of the cellular targets of bioactive small molecules is a crucial step in drug
discovery and chemical genetics. Classical affinity purification with small-molecule affinity …