Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

The rapid emergence and dissemination of multidrug-resistant (MDR) bacterial pathogens
pose a serious threat to global healthcare. One particular concern is the carbapenem …

Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …

Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration
combined with safety and few, yet rare, unwanted effects, have made the quinolones class of …

In recent years, traditional antibiotic efficacy has rapidly diminished due to the advent of
multidrug‐resistant (MDR) bacteria, which poses severe threat to human life and globalized …

The global incidence of drug-resistant Gram-negative bacillary infections has been
increasing, and there is a dire need to develop novel strategies to overcome this problem …

The antimicrobial resistance crisis is a global health issue requiring discovery and
development of novel therapeutics. However, conventional screening of natural products or …

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

New approaches to target antibacterial agents toward Gram-negative bacteria are key, given
the rise of antibiotic resistance. Since the discovery of polymyxin B nonapeptide as a potent …