Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks
by catalyzing the substitution of the 2′ OH-group of a ribonucleotide with a hydrogen by a …

Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of
ribonucleotides to 2′-deoxyribonucleotides and thereby provides the precursors needed …

Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the first
double bond into saturated fatty acyl-CoAs,,,. Because the monounsaturated products of …

Though an essential trace element, manganese is generally accorded little importance in
biology other than as a cofactor for some free radical detoxifying enzymes and in the …

Cyclic alkyl (amino) carbene stabilized two-and three-coordinate Fe (I) complexes,(cAAC)
2FeCl (2) and [(cAAC) 2Fe][B (C6F5) 4](3), respectively, were prepared and thoroughly …

How cells ensure correct metallation of a given protein and whether a degree of promiscuity
in metal binding has evolved are largely unanswered questions. In a classic case, iron-and …

The structure of a protein determines its function and its interactions with other factors.
Regions of proteins that interact with ligands, substrates, and/or other proteins, tend to be …

In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase
(RNR), the enzyme responsible for biosynthesis of the 2′-deoxynucleotide building blocks …

Fatty acid desaturase catalyzes the desaturation reactions by inserting double bonds into
the fatty acyl chain, producing unsaturated fatty acids, which play a vital part in the synthesis …

Aerobic ribonucleotide reductases (RNRs) initiate synthesis of DNA building blocks by
generating a free radical within the R2 subunit; the radical is subsequently shuttled to the …