Global burden of hepatitis B virus: current status, missed opportunities and a call for action

YC Hsu, DQ Huang, MH Nguyen - Nature reviews Gastroenterology & …, 2023 - nature.com
Chronic hepatitis B virus (HBV) infection affects about 296 million people worldwide and is
the leading aetiology of cirrhosis and liver cancer globally. Major medical complications also …

Immunobiology and pathogenesis of hepatitis B virus infection

M Iannacone, LG Guidotti - Nature Reviews Immunology, 2022 - nature.com
Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

How to achieve functional cure of HBV: stop** NUCs, adding interferon or new drug development?

GLH Wong, E Gane, ASF Lok - Journal of hepatology, 2022 - Elsevier
Functional cure of hepatitis B is defined as sustained undetectable circulating HBsAg and
HBV DNA after a finite course of treatment. Barriers to HBV cure include the reservoirs for …

A global scientific strategy to cure hepatitis B

PA Revill, FV Chisari, JM Block, M Dandri… - The lancet …, 2019 - thelancet.com
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …

Global burden of NAFLD and chronic liver disease among adolescents and young adults

JM Paik, K Kabbara, KE Eberly, Y Younossi… - …, 2022 - Wiley Online Library
Abstract Background and Aim The causes of chronic liver disease (CLD) among adults have
changed. Data are lacking on trends among youth. We determined the trends and changes …

[HTML][HTML] Update of the statements on biology and clinical impact of occult hepatitis B virus infection

G Raimondo, S Locarnini, T Pollicino, M Levrero… - Journal of …, 2019 - Elsevier
In October 2018 a large number of international experts with complementary expertise came
together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI) …

Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update

SK Sarin, M Kumar, GK Lau, Z Abbas, HLY Chan… - Hepatology …, 2016 - Springer
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest
rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection …

Hepatitis B reactivation associated with immune suppressive and biological modifier therapies: current concepts, management strategies, and future directions

R Loomba, TJ Liang - Gastroenterology, 2017 - Elsevier
Hepatitis B reactivation associated with immune-suppressive and biological therapies is
emerging to be an important cause of morbidity and mortality in patients with current or prior …

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

M Nassal - Gut, 2015 - gut.bmj.com
At least 250 million people worldwide are chronically infected with HBV, a small
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …

[HTML][HTML] Molecular biology of hepatitis B virus infection

C Seeger, WS Mason - Virology, 2015 - Elsevier
Human hepatitis B virus (HBV) is the prototype of a family of small DNA viruses that
productively infect hepatocytes, the major cell of the liver, and replicate by reverse …