Superoxide anion chemistry—Its role at the core of the innate immunity

CMC Andrés, JM Pérez de la Lastra… - International journal of …, 2023 - mdpi.com
Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …

The role of macrophage subtypes and exosomes in immunomodulation

AT Gharavi, NA Hanjani, E Movahed… - Cellular & molecular …, 2022 - Springer
Macrophages are influential members of the innate immune system that can be reversibly
polarized by different microenvironment signals. Cell polarization leads to a wide range of …

[HTML][HTML] The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review

H Liao, J Ye, L Gao, Y Liu - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Scutellaria baicalensis Georgi., a plant used in traditional Chinese medicine, has multiple
biological activities, including anti-inflammatory, antiviral, antitumor, antioxidant, and …

Hepatic macrophages: Key players in the development and progression of liver fibrosis

D Cheng, J Chai, H Wang, L Fu, S Peng… - Liver …, 2021 - Wiley Online Library
Hepatic fibrosis is a common pathological process involving persistent liver injury with
various etiologies and subsequent inflammatory responses that occur in chronic liver …

Macrophage polarization in cardiac tissue repair following myocardial infarction

Y Kim, S Nurakhayev, A Nurkesh… - International journal of …, 2021 - mdpi.com
Cardiovascular disease is the leading cause of mortality and morbidity around the globe,
creating a substantial socio-economic burden as a result. Myocardial infarction is a …

The role of macrophages in the pathogenesis of SARS-CoV-2-associated acute respiratory distress syndrome

A Kosyreva, D Dzhalilova, A Lokhonina… - Frontiers in …, 2021 - frontiersin.org
Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a
major role in both physiological and pathological processes. Systemic SARS-CoV-2 …

Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease

G Giuliani, M Rosina, A Reggio - The FEBS journal, 2022 - Wiley Online Library
The characterization of fibro/adipogenic progenitor cells (FAPs) in the skeletal muscle has
contributed to modify the monocentric view of muscle regeneration beyond muscle satellite …

Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach

AN Chamseddine, T Assi, O Mir, S Chouaib - Pharmacology & therapeutics, 2022 - Elsevier
Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …

Macrophage modification strategies for efficient cell therapy

AS Poltavets, PA Vishnyakova, AV Elchaninov… - Cells, 2020 - mdpi.com
Macrophages, important cells of innate immunity, are known for their phagocytic activity,
capability for antigen presentation, and flexible phenotypes. Macrophages are found in all …

Macrophages and foam cells: Brief overview of their role, linkage, and targeting potential in atherosclerosis

AV Poznyak, NG Nikiforov, AV Starodubova… - Biomedicines, 2021 - mdpi.com
Atherosclerosis is still one of the main causes of death around the globe. This condition
leads to various life-threatening cardiovascular complications. However, no effective …