Huntington's disease is an autosomal-dominant, progressive neurodegenerative disorder
with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline …

Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormally
elongated polyglutamine (polyQ) tract in the large protein huntingtin (htt). Currently, both the …

At least nine inherited neurodegenerative diseases share a polyglutamine expansion in
their respective disease proteins. These diseases show distinct neuropathological changes …

Huntington's disease (HD) is caused by an expansion of cytosine–adenine–guanine (CAG)
repeats in the huntingtin gene, which leads to neuronal loss in the striatum and cortex and to …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …

Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the
progressive development of involuntary choreiform movements, cognitive impairment …

Defects in gene transcription and mitochondrial function have been implicated in the
dominant disease process that leads to the loss of striatal neurons in Huntington's disease …

Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin.
In its terminal stage, HD is characterized by widespread neuronal death in the neocortex …

Two serine residues within the first 17 amino acid residues of huntingtin (N17) are crucial for
modulation of mutant huntingtin toxicity in cell and mouse genetic models of Huntington's …

Recent developments in our understanding of the pathophysiological mechanisms
underlying degeneration in both the central and peripheral nervous systems have …