Cellular sources of TSPO expression in healthy and diseased brain
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
Anxiety and brain mitochondria: a bidirectional crosstalk
Accumulating data highlight the contribution of brain mitochondria and bioenergetics to
psychiatric disorders and stress-related pathologies. Although anxiety has not received …
psychiatric disorders and stress-related pathologies. Although anxiety has not received …
Mitochondrial dynamics and psychiatric disorders: The missing link
Elucidating the molecular mechanisms of psychopathology is crucial for optimized diagnosis
and treatment. Accumulating literature has underlined how mitochondrial bioenergetics …
and treatment. Accumulating literature has underlined how mitochondrial bioenergetics …
Translocator protein (18 kDa): an update on its function in steroidogenesis
Translocator protein (18 kDa)(TSPO) is a ubiquitous mitochondrial protein. Studies of its
responses to drug and endogenous ligands have shown TSPO to be involved either directly …
responses to drug and endogenous ligands have shown TSPO to be involved either directly …
Microglial pro-inflammatory and anti-inflammatory phenotypes are modulated by translocator protein activation
E Da Pozzo, C Tremolanti, B Costa… - International journal of …, 2019 - mdpi.com
A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation
has been recently proposed. However, little is known about TSPO-activated pathways …
has been recently proposed. However, little is known about TSPO-activated pathways …
TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis
The 18 kDa translocator protein (TSPO) is a ubiquitous conserved outer mitochondrial
membrane protein implicated in numerous cell and tissue functions, including steroid …
membrane protein implicated in numerous cell and tissue functions, including steroid …
Endozepines and their receptors: structure, functions and pathophysiological significance
The existence of specific binding sites for benzodiazepines (BZs) in the brain has prompted
the search for endogenous BZ receptor ligands designated by the generic term …
the search for endogenous BZ receptor ligands designated by the generic term …
An update into the medicinal chemistry of translocator protein (TSPO) ligands
Abstract The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …
Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema
Lipedema is an often underdiagnosed chronic disorder that affects subcutaneous adipose
tissue almost exclusively in women, which leads to disproportionate fat accumulation in the …
tissue almost exclusively in women, which leads to disproportionate fat accumulation in the …
Cardiac-specific conditional knockout of the 18-kDa mitochondrial translocator protein protects from pressure overload induced heart failure
PN Thai, DJ Daugherty, BJ Frederich, X Lu, W Deng… - Scientific reports, 2018 - nature.com
Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca2+) handling,
energy failure and impaired mitophagy resulting in contractile dysfunction and myocyte …
energy failure and impaired mitophagy resulting in contractile dysfunction and myocyte …