Traditional therapeutic approaches such as chemotherapy and radiation therapy have
burdened cancer patients with onerous physical and psychological challenges …

The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

Mutations in the tumor-suppressor genes BRCA1 and BRCA2 resulting in BRCA1/2
deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other …

Background Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer,
and chemoresistance poses a significant challenge to the survival and prognosis of GBM …

Background and objective Recently, research on treatment intensification has gathered
momentum, and three novel therapy combinations were approved for metastatic castration …

Cancer drug resistance stands as a formidable obstacle in the relentless fight against the top
five prevalent cancers: breast, lung, colorectal, prostate, and gastric cancers. These …

Currently available PARP inhibitors are mainly used for the treatment of BRCA-mutated
triple-negative breast cancer (TNBC), with a narrow application range of approximately 15 …

Ovarian high-grade serous carcinoma (HGSC) is the most common subtype of ovarian
cancer with limited therapeutic options and a poor prognosis. In recent years, poly-ADP …

ATR is a key kinase in the DNA-damage response (DDR) that is synthetic lethal with several
other DDR proteins, making it an attractive target for the treatment of genetically selected …