PDZ domains are protein-interaction domains that are often found in multi-domain
scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large …

PDZ domains are abundant protein interaction modules that often recognize short amino
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …

Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors
activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different …

The ADP ribosylation factors (Arfs) are a family of small, ubiquitously expressed and
evolutionarily conserved guanosine triphosphatases that are key regulators of vesicular …

Almost 25 years after the first report that glutamate can activate receptors coupled to
heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic …

PDZ proteins, named for the common structural domain shared by the postsynaptic density
protein (PSD95), Drosophila disc large tumor suppressor (DlgA), and zonula occludens-1 …

Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to
activation of a wide variety of signalling pathways. mGluRs couple to Gαq/11 proteins …

ABSTARCT G protein–coupled receptors (GPCRs) contribute to the regulation of every
aspect of human physiology and are therapeutic targets for the treatment of numerous …

The plethora of functions of glutamate in the brain are mediated by the complementary
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …

Importance Schizophrenia is a complex genetic disorder demonstrating considerable
heritability. Genetic studies have implicated many different genes and pathways, but much of …