Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms
Covering: through 2014 Many organisms team up with microbes for defense against
predators, parasites, parasitoids, or pathogens. Here we review the described protective …
predators, parasites, parasitoids, or pathogens. Here we review the described protective …
[HTML][HTML] Immune properties of invertebrate phenoloxidases
Melanin production from different types of phenoloxidases (POs) confers immunity from a
variety of pathogens ranging from viruses and microorganisms to parasites. The arthropod …
variety of pathogens ranging from viruses and microorganisms to parasites. The arthropod …
Diversity and natural functions of antibiotics produced by beneficial and plant pathogenic bacteria
JM Raaijmakers, M Mazzola - Annual review of phytopathology, 2012 - annualreviews.org
Soil-and plant-associated environments harbor numerous bacteria that produce antibiotic
metabolites with specific or broad-spectrum activities against coexisting microorganisms …
metabolites with specific or broad-spectrum activities against coexisting microorganisms …
The proPO-system: pros and cons for its role in invertebrate immunity
Melanisation is an important immune response in many invertebrates. Recent evidence also
strongly implies that the melanisation (prophenoloxidase activating) cascade is intimately …
strongly implies that the melanisation (prophenoloxidase activating) cascade is intimately …
Insect prophenoloxidase: the view beyond immunity
A Lu, Q Zhang, J Zhang, B Yang, K Wu, W **e… - Frontiers in …, 2014 - frontiersin.org
Insect prophenoloxidase (PPO) is an important innate immunity protein due to its
involvement in cellular and humoral defense. It belongs to a group of type-3 copper …
involvement in cellular and humoral defense. It belongs to a group of type-3 copper …
Metabolites from symbiotic bacteria
J Piel - Natural product reports, 2009 - pubs.rsc.org
Metabolites from symbiotic bacteria - Natural Product Reports (RSC Publishing) DOI:10.1039/B703499G
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B703499G …
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B703499G …
Proteolytic cascades and their involvement in invertebrate immunity
L Cerenius, S Kawabata, BL Lee, M Nonaka… - Trends in biochemical …, 2010 - cell.com
Bacteria and other potential pathogens are cleared rapidly from the body fluids of
invertebrates by the immediate response of the innate immune system. Proteolytic cascades …
invertebrates by the immediate response of the innate immune system. Proteolytic cascades …
Regulation of stilbene biosynthesis in plants
AS Dubrovina, KV Kiselev - Planta, 2017 - Springer
Main conclusion This review analyzes the advances in understanding the natural signaling
pathways and environmental factors regulating stilbene biosynthesis. We also discuss the …
pathways and environmental factors regulating stilbene biosynthesis. We also discuss the …
Entomopathogenic bacteria as a source of secondary metabolites
HB Bode - Current opinion in chemical biology, 2009 - Elsevier
Insects are not only the most diverse group of animals on our planet, but also a huge
reservoir for unusual microorganism which are a rich source of pharmaceutically interesting …
reservoir for unusual microorganism which are a rich source of pharmaceutically interesting …