METTLing in stem cell and cancer biology

JG Tooley, JP Catlin, CES Tooley - Stem cell reviews and reports, 2023 - Springer
The methyltransferase-like (METTL) family is a diverse group of methyltransferases that can
methylate nucleotides, proteins, and small molecules. Despite this diverse array of …

Three's a crowd–why did three N-terminal methyltransferases evolve for one job?

MM Conner, CE Schaner Tooley - Journal of Cell Science, 2023 - journals.biologists.com
ABSTRACT N-terminal methylation of the α-amine group (Nα-methylation) is a post-
translational modification (PTM) that was discovered over 40 years ago. Although it is not the …

CREB1 promotes proliferation and differentiation by mediating the transcription of CCNA2 and MYOG in bovine myoblasts

YR Feng, SHA Raza, CC Liang, XY Wang… - International Journal of …, 2022 - Elsevier
The cAMP response element binding protein 1 (CREB1) is an important nuclear
transcription factor in eukaryotes. To explore the potential role of CREB1 on Qinchuan …

Opposing regulation of the Nα-trimethylase METTL11A by its family members METTL11B and METTL13

HV Parker, CES Tooley - Journal of Biological Chemistry, 2023 - ASBMB
N-terminal protein methylation (Nα-methylation) is a posttranslational modification that
influences numerous biological processes by regulating protein stability, protein–DNA …

Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell …

JP Catlin, LN Marziali, B Rein, Z Yan, ML Feltri… - Cell death & …, 2021 - nature.com
N-terminal methylation is an important posttranslational modification that regulates
protein/DNA interactions and plays a role in many cellular processes, including DNA …

Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players

Z Chen, J Li, Y Bai, Z Liu, Y Wei, D Guo, X Jia… - International Journal of …, 2024 - mdpi.com
Muscle formation directly determines meat production and quality. The non-SMC condensin
I complex subunit G (NCAPG) is strongly linked to the growth features of domestic animals …

Integrative analysis of whole genome bisulfite and transcriptome sequencing reveals the effect of sodium butyrate on DNA methylation in the differentiation of bovine …

X Wang, X Zhou, C Li, C Qu, Y Shi, CJ Li, X Kang - Genomics, 2024 - Elsevier
Butyric acid as a short-chain fatty acid (SCFA) is one of the key microbial metabolites of
ruminants. Numerous studies indicate that butyrate is crucial in muscle growth and …

Structure–activity relationship studies of venglustat on NTMT1 inhibition

Y Deng, G Dong, Y Meng, N Noinaj… - Journal of medicinal …, 2023 - ACS Publications
The protein N-terminal methyltransferase 1 (NTMT1) is implicated in neurogenesis,
retinoblastoma, and cervical cancer. However, its pharmacological potentials have not been …

Opposing regulation of METTL11A by its family members METTL11B and METTL13

HV Parker, CE Schaner Tooley - bioRxiv, 2022 - biorxiv.org
N-terminal protein methylation (Nα-methylation) is a post-translational modification (PTM)
that influences a variety of biological processes by regulating protein stability, protein-DNA …

Meat quality, fatty acid profile and genomic insight of Busha cattle in extensive production systems in Serbia.

M MARINKOVIĆ, I ŽIVOTIĆ, DO ANDRIĆ… - …, 2024 - search.ebscohost.com
Identification of SNPs and effective genes associated with meat quality traits and fatty acid
(FA) profiles can help in the selection of animals with the best potential. In this study, we …