The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

The extracellular matrix (ECM) is an abundant noncellular component of most solid tumors
known to support tumor progression and metastasis. The interplay between the ECM and …

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …

Collagen is one of the most abundant proteins in animals and a major component of the
extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of …

Cervical cancer, primarily squamous cell carcinoma, is the most prevalent gynecologic
malignancy. Organoids can mimic tumor development in vitro, but current Matrigel …

Osteosarcoma is the most common bone tumor that leads to high mortality in adolescents
and children. The tRNA N7-methylguanosine methyltransferase METTL1 is located in …

The tumor physical microenvironment (TPME) contributes to cancer chemoresistance in both
mechanical and mechanobiological approaches. Along with chemotherapy, the tumor …

Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …