Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

The successful clinical application of immune checkpoint blockade (ICB) and chimeric
antigen receptor T cells (CAR-T) therapeutics has attracted extensive attention to …

High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

Immunotherapy has become a promising research “hotspot” in cancer treatment.“Soldier”
immune cells are not uniform throughout the body; they accumulate mostly in the immune …

Immunotherapy has emerged as a potent strategy in cancer treatment, with many approved
drugs and modalities in the development stages. Despite its promise, immunotherapy is not …

Designing and manufacturing safe and effective vaccines is a crucial challenge for human
health worldwide. Research on adjuvant-based subunit vaccines is increasingly being …

With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence
shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit …

High endothelial venules (HEVs) are specialized postcapillary venules composed of
cuboidal blood endothelial cells that express high levels of sulfated sialomucins to bind L …

The deposition of immune complexes, activation of complement and infiltration of the kidney
by cells of the adaptive and innate immune systems have long been considered responsible …

Therapeutic efficacy for prostate cancer is highly restricted by insufficient drug accumulation
and the resistance to apoptosis and immunogenic cell death (ICD). Although enhanced …