Environmental factors in declining human fertility
A severe decline in child births has occurred over the past half century, which will lead to
considerable population declines, particularly in industrialized regions. A crucial question is …
considerable population declines, particularly in industrialized regions. A crucial question is …
Targeting GSK3 and associated signaling pathways involved in cancer
P Duda, SM Akula, SL Abrams, LS Steelman… - Cells, 2020 - mdpi.com
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although
GSK-3 originally was identified to have functions in regulation of glycogen synthase, it was …
GSK-3 originally was identified to have functions in regulation of glycogen synthase, it was …
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases
L Wang, J Li, L Di - Medicinal Research Reviews, 2022 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …
Signaling mechanisms in mammalian sperm motility
MJ Freitas, S Vijayaraghavan… - Biology of …, 2017 - academic.oup.com
The goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in
the epididymis and hyperactivated motility in the female reproductive tract. Motility is only …
the epididymis and hyperactivated motility in the female reproductive tract. Motility is only …
Metabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma
KM Engel, S Baumann, U Rolle-Kampczyk, J Schiller… - PloS one, 2019 - journals.plos.org
In 50% of all infertility cases, the male is subfertile or infertile, however, the underlying
mechanisms are often unknown. Even when assisted reproductive procedures such as in …
mechanisms are often unknown. Even when assisted reproductive procedures such as in …
[HTML][HTML] The role of GSK3 in metabolic pathway perturbations in cancer
Malignant transformation and tumor progression are accompanied by significant
perturbations in metabolic programs. As such, cancer cells support high ATP turnover to …
perturbations in metabolic programs. As such, cancer cells support high ATP turnover to …
Chlormequat chloride induced activation of calmodulin mediated PI3K/AKT signaling pathway led to impaired sperm quality in pubertal mice
X Wang, C Kang, W Guo, L Yuan, H Zhang… - Food and Chemical …, 2024 - Elsevier
Chlormequat chloride (CCC), as a widely used plant growth regulator, can cause impaired
sperm quality and decreased testosterone synthesis in pubertal rats, but the underlying …
sperm quality and decreased testosterone synthesis in pubertal rats, but the underlying …
[HTML][HTML] Emerging roles of GSK-3α in pathophysiology: Emphasis on cardio-metabolic disorders
Abstract Glycogen synthase kinase-3 (GSK-3) is a widely expressed serine/threonine kinase
regulates a variety of cellular processes including proliferation, differentiation and death …
regulates a variety of cellular processes including proliferation, differentiation and death …
Signaling enzymes required for sperm maturation and fertilization in mammals
S Dey, C Brothag, S Vijayaraghavan - Frontiers in Cell and …, 2019 - frontiersin.org
In mammals, motility and fertilizing ability of spermatozoa develop during their passage
through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in …
through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in …
In silico analysis of the effects of non-synonymous SNPs associated with human GSK3B gene on its structure and function
M Kumar, R Bharti, GK Azad - Human Gene, 2024 - Elsevier
Abstract Single Nucleotide Polymorphisms (SNPs) are abundantly identified by next
generation sequencing (NGS) technology. Glycogen synthase kinase-3 beta (GSK3B), a …
generation sequencing (NGS) technology. Glycogen synthase kinase-3 beta (GSK3B), a …