Multiple protein families, each with a distinct function, provide the traffic signals for
leukocytes. The selectin family of adhesion molecules (Figure 2) has an N-terminal domain …

The circulatory and migratory properties of white blood cells have evolved to allow efficient
surveillance of tissues for infectious pathogens and rapid accu ญ mulation at sites of injury …

Rolling of leukocytes on vascular endotheliai cells, an early event in inflammation, can be
reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named …

The expression of PECAM, ICAM‐1, VCAM‐1, and E‐selectin was studied in 64 samples of
human coronary arteries taken from 15 explanted hearts obtained within 5 min of …

Perspectives Page 1 Perspectives Selectins Michael P. Bevilacqua and Richard M. Nelson
Howard Hughes Medical Institute, Cellular and Molecular Medicine andDepartment ofPathology …

L-selectin, a cell adhesion molecule expressed by leukocytes, mediates the attachment of
lymphocytes to high endothelial venules (HEV) of peripheral lymph nodes and mediates the …

Although a bewildering array of cell surface carbohydrate structures have been described,
the physiological relevance of any of these complex molecules has often eluded biologists …

The selectins initiate many critical interactions among blood cells. The volume of information
and diversity of opinions on the nature of the biologically relevant ligands for selectins is …

The human cytokine interferon-inducible protein 10 (IP-10) is a small glycoprotein secreted
by activated T cells, monocytes, endothelial cells, and keratinocytes, and is structurally …

Selectins have previously been shown to tether a flowing leukocyte to a vessel wall and
mediate rolling. Here, we report that an intergrin, VLA-4, can also support tethering and …