Autophagy and autophagy-related proteins in cancer

X Li, S He, B Ma - Molecular cancer, 2020 - Springer
Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

Mechanisms of autophagy

NN Noda, F Inagaki - Annual review of biophysics, 2015 - annualreviews.org
The formation of the autophagosome, a landmark event in autophagy, is accomplished by
the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in …

Guidelines for the use and interpretation of assays for monitoring autophagy

DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin… - Autophagy, 2016 - escholarship.org
Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …

WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12–5-16L1

HC Dooley, M Razi, HEJ Polson, SE Girardin… - Molecular cell, 2014 - cell.com
Mammalian cell homeostasis during starvation depends on initiation of autophagy by
endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns (3) P) synthesis …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

[HTML][HTML] Guidelines for the use and interpretation of assays for monitoring autophagy 1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah… - …, 2021 - pmc.ncbi.nlm.nih.gov
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation

K Morita, Y Hama, T Izume, N Tamura, T Ueno… - Journal of Cell …, 2018 - rupress.org
Macroautophagy is an intracellular degradation process that requires multiple autophagy-
related (ATG) genes. In this study, we performed a genome-wide screen using the …

Autophagy signal transduction by ATG proteins: from hierarchies to networks

S Wesselborg, B Stork - Cellular and molecular life sciences, 2015 - Springer
Autophagy represents an intracellular degradation process which is involved in both cellular
homeostasis and disease settings. In the last two decades, the molecular machinery …

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

CJ Shoemaker, TQ Huang, NR Weir, NJ Polyakov… - PLoS …, 2019 - journals.plos.org
The power of forward genetics in yeast is the foundation on which the field of autophagy
research firmly stands. Complementary work on autophagy in higher eukaryotes has …

[HTML][HTML] Regulation of autophagy by signaling through the Atg1/ULK1 complex

D Papinski, C Kraft - Journal of molecular biology, 2016 - Elsevier
Autophagy is an intracellular degradation pathway highly conserved in eukaryotic species. It
is characterized by selective or bulk trafficking of cytosolic structures—ranging from single …