Guide to metabolomics analysis: a bioinformatics workflow

Y Chen, EM Li, LY Xu - Metabolites, 2022 - mdpi.com
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

Chronic tissue inflammation and metabolic disease

YS Lee, J Olefsky - Genes & development, 2021 - genesdev.cshlp.org
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …

Large-scale association analyses identify host factors influencing human gut microbiome composition

A Kurilshikov, C Medina-Gomez, R Bacigalupe… - Nature …, 2021 - nature.com
To study the effect of host genetics on gut microbiome composition, the MiBioGen
consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data …

[HTML][HTML] The potential of metabolomics in biomedical applications

V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

[HTML][HTML] Food polyphenols and type II diabetes mellitus: pharmacology and mechanisms

R Naz, F Saqib, S Awadallah, M Wahid, MF Latif, I Iqbal… - Molecules, 2023 - mdpi.com
Type II diabetes mellitus and its related complications are growing public health problems.
Many natural products present in our diet, including polyphenols, can be used in treating …

Recent developments in biomarkers for diagnosis and screening of type 2 diabetes mellitus

M Ortiz-Martínez, M González-González… - Current diabetes …, 2022 - Springer
Abstract Purpose of Review Diabetes mellitus is a complex, chronic illness characterized by
elevated blood glucose levels that occurs when there is cellular resistance to insulin action …

Gut microbiota: A new target for T2DM prevention and treatment

L Liu, J Zhang, Y Cheng, M Zhu, Z **ao… - Frontiers in …, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM), one of the fastest growing metabolic diseases, has been
characterized by metabolic disorders including hyperglycemia, hyperlipidemia and insulin …

Multi-omics integration in biomedical research–A metabolomics-centric review

MA Wörheide, J Krumsiek, G Kastenmüller… - Analytica chimica …, 2021 - Elsevier
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …

Metabolomics and metabolic diseases: where do we stand?

CB Newgard - Cell metabolism, 2017 - cell.com
Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …

Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis

M Guasch-Ferré, A Hruby, E Toledo, CB Clish… - Diabetes …, 2016 - diabetesjournals.org
OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …