Recent progress in translational engineered in vitro models of the central nervous system

P Nikolakopoulou, R Rauti, D Voulgaris, I Shlomy… - Brain, 2020 - academic.oup.com
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

[HTML][HTML] Progressive resistance exercise improves strength and physical performance in people with mild to moderate Parkinson's disease: a systematic review

LO Lima, A Scianni, F Rodrigues-de-Paula - Journal of physiotherapy, 2013 - Elsevier
Question Does progressive resistance exercise improve strength and measures of physical
performance in people with Parkinson's disease? Design Systematic review with meta …

Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons

T Osaki, SGM Uzel, RD Kamm - Science advances, 2018 - science.org
Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease involving loss
of motor neurons (MNs) and muscle atrophy, still has no effective treatment, despite much …

Altered pharyngeal muscles in Parkinson disease

L Mu, S Sobotka, J Chen, H Su… - … of Neuropathology & …, 2012 - academic.oup.com
Dysphagia (impaired swallowing) is common in patients with Parkinson disease (PD) and is
related to aspiration pneumonia, the primary cause of death in PD. Therapies that …

Comparison of synergy extrapolation and static optimization for estimating multiple unmeasured muscle activations during walking

D Ao, BJ Fregly - Journal of NeuroEngineering and Rehabilitation, 2024 - Springer
Background Calibrated electromyography (EMG)-driven musculoskeletal models can
provide insight into internal quantities (eg, muscle forces) that are difficult or impossible to …

Parkinson's Disease‐Induced Zebrafish Models: Focussing on Oxidative Stress Implications and Sleep Processes

MA Robea, IM Balmus, A Ciobica… - Oxidative Medicine …, 2020 - Wiley Online Library
The complex yet not fully understood pathophysiology of Parkinson's disease includes an
important molecular component consisting of oxidative status changes, thus leading to …

Parkinson's disease and osteoporosis

F Van Den Bos, AD Speelman, M Samson… - Age and …, 2013 - academic.oup.com
Background: patients with Parkinson's disease (PD) have a high risk of sustaining
osteoporotic fractures as a result of falls and reduced bone mass. Objective: to summarise …

Could heat therapy be an effective treatment for Alzheimer's and Parkinson's diseases? A narrative review

AP Hunt, GM Minett, OR Gibson, GK Kerr… - Frontiers in …, 2020 - frontiersin.org
Neurodegenerative diseases involve the progressive deterioration of structures within the
central nervous system responsible for motor control, cognition, and autonomic function …

Muscle strength and power in people with Parkinson disease: a systematic review and meta-analysis

M Gamborg, LG Hvid, C Thrue… - Journal of Neurologic …, 2023 - journals.lww.com
Background and Purpose: No studies have synthesized the literature regarding mechanical
muscle function (ie, strength, power, rate of force development [RFD]) in people with …

Quadriceps muscle weakness, activation deficits, and fatigue with Parkinson disease

J Stevens-Lapsley, BM Kluger… - … and Neural Repair, 2012 - journals.sagepub.com
Background. People with Parkinson disease (PD) typically have complaints of weakness.
The mechanisms underlying this deficit have not been well established, although many …