Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Alzheimer's disease (AD) is characterized by cognitive impairment, progressive
neurodegeneration and formation of amyloid-β (Aβ)-containing plaques and neurofibrillary …

Lysosomes are organelles central to degradation and recycling processes in animal cells.
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …

Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived
proteins, is a key determinant of cell survival and longevity. In this study, we show that …

Frontotemporal dementia (FTD) because of MAPT mutation causes pathological
accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We …

Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely
explored. Here, we show that a muscle secretory factor, cathepsin B (CTSB) protein, is …

Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD),
and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired …

Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural
development, differentiation and synaptic plasticity. However, excessive stimulation of …

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …

We explored the relationship between ubiquitin proteasome system (UPS) and lysosomal
markers and the formation of α-synuclein (α-syn) inclusions in nigral neurons in Parkinson …