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Recent efforts in the discovery of urease inhibitor identifications
WQ Song, ML Liu, SY Li, ZP **ao - Current Topics in Medicinal …, 2022 - benthamdirect.com
Urease is an attractive drug target for designing anti-infective agents against pathogens
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
Synthetic Transformation of 2-{2-Fluoro[1,1′-biphenyl]-4-yl} Propanoic Acid into Hydrazide–Hydrazone Derivatives: In Vitro Urease Inhibition and In Silico Study
In the present study, 28 acyl hydrazones (4–31) of flurbiprofen were synthesized in good to
excellent yield by reacting different aromatic aldehydes with the commercially available drug …
excellent yield by reacting different aromatic aldehydes with the commercially available drug …
New Anthranilic Acid Hydrazones as Fenamate Isosteres: Synthesis, Characterization, Molecular Docking, Dynamics & in Silico ADME, in Vitro Anti‐Inflammatory …
H Şenol, Z Çağman… - Chemistry & …, 2023 - Wiley Online Library
In this study, twenty new anthranilic acid hydrazones 6–9 (a–e) were synthesized and their
structures were characterized by Fourier‐transform Infrared (FT‐IR), Nuclear Magnetic …
structures were characterized by Fourier‐transform Infrared (FT‐IR), Nuclear Magnetic …
[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis, pharmacological …
M Khalili Ghomi, M Noori, M Nazari Montazer… - Scientific Reports, 2023 - nature.com
Regarding the important role of the urease enzyme as a virulence factor in urease-positive
microorganisms in this study, new series of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole …
microorganisms in this study, new series of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole …
An overview of the privileged synthetic heterocycles as urease enzyme inhibitors: structure–activity relationship
S Sepehri, M Khedmati - Archiv der Pharmazie, 2023 - Wiley Online Library
Urease is a metalloenzyme including two Ni2+ ions, found in some plants, bacteria, fungi,
microorganisms, invertebrate animals, and animal tissues. Urease acts as a significant …
microorganisms, invertebrate animals, and animal tissues. Urease acts as a significant …
Design and synthesis of new N-thioacylated ciprofloxacin derivatives as urease inhibitors with potential antibacterial activity
A new series of N-thioacylated ciprofloxacin 3a–n were designed and synthesized based on
Willgerodt–Kindler reaction. The results of in vitro urease inhibitory assay indicated that …
Willgerodt–Kindler reaction. The results of in vitro urease inhibitory assay indicated that …
Different barbiturate derivatives linked to aryl hydrazone moieties as urease inhibitors; design, synthesis, urease inhibitory evaluations, and molecular dynamic …
New series of barbiturates linked to aryl hydrazone derivatives 4a-n were designed and
synthesized. Briefly, aniline derivatives in the presence of HBF4 and NaNO2 convert to aryl …
synthesized. Briefly, aniline derivatives in the presence of HBF4 and NaNO2 convert to aryl …
Design and synthesis of novel nitrothiazolacetamide conjugated to different thioquinazolinone derivatives as anti-urease agents
The present article describes the design, synthesis, in vitro urease inhibition, and in silico
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
New thioxothiazolidinyl-acetamides derivatives as potent urease inhibitors: Design, synthesis, in vitro inhibition, and molecular dynamic simulation
N Dastyafteh, M Noori, M Nazari Montazer… - Scientific Reports, 2023 - nature.com
To identify potent urease inhibitors, in the current study, a series of thioxothiazolidinyl-
acetamides were designed and synthesized. The prepared compounds were characterized …
acetamides were designed and synthesized. The prepared compounds were characterized …
Synthesis and in vitro urease inhibitory activity of 5-nitrofuran-2-yl-thiadiazole linked to different cyclohexyl-2-(phenylamino) acetamides, in silico and kinetic studies
Abstract A series of 5-nitrofuran-2-yl-thiadiazole linked to different cyclohexyl-2-
(phenylamino) acetamides were rationally designed and synthesized. All synthetic …
(phenylamino) acetamides were rationally designed and synthesized. All synthetic …