Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

Thyroid hormone biosynthesis, storage, and secretion require a series of highly regulated
steps. Iodide, the rate-limiting substrate for thyroid hormone synthesis, is actively transported …

Pituitary stalk interruption syndrome (PSIS) is a congenital pituitary anatomical defect. This
syndrome is an antenatal developmental defect belonging to the holoprosencephaly …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis.
The development of the pituitary gland depends on the sequential temporal and spatial …

Obesity is an escalating epidemic, but an effective noninvasive therapy is still scarce. For
obesity treatment, anorexigenic neuropeptides are promising tools, but their delivery from …

The development of the anterior pituitary gland occurs in distinct sequential developmental
steps, leading to the formation of a complex organ containing five different cell types …

Mutations in the PROP1 transcription factor gene lead to reduced production of thyrotropin,
GH, prolactin, and gonadotropins as well as to pituitary hypoplasia in adult humans and …

Growth hormone deficiency (GHD) may result from a failure of hypothalamic GHRH
production or release, from congenital disorders of pituitary development, or from central …

The somatotropic axis is the central postnatal regulator of longitudinal growth. One of its
major components–growth hormone–is produced by the anterior lobe of the pituitary, which …