Polyploidy in liver development, homeostasis and disease

R Donne, M Saroul-Aïnama, P Cordier… - Nature reviews …, 2020 - nature.com
Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

Uterine glands: developmental biology and functional roles in pregnancy

AM Kelleher, FJ DeMayo, TE Spencer - Endocrine reviews, 2019 - academic.oup.com
All mammalian uteri contain glands in the endometrium that develop only or primarily after
birth. Gland development or adenogenesis in the postnatal uterus is intrinsically regulated …

Polyploidy in tissue homeostasis and regeneration

JI Øvrebø, BA Edgar - Development, 2018 - journals.biologists.com
Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …

Embryo-derive TNF promotes decidualization via fibroblast activation

ST Chen, WW Shi, YQ Lin, ZS Yang, Y Wang, MY Li… - Elife, 2023 - elifesciences.org
Decidualization is a process in which endometrial stromal fibroblasts differentiate into
specialized secretory decidual cells and essential for the successful establishment of …

Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade

Y **, T Anbarchian, P Wu, A Sarkar… - Proceedings of the …, 2022 - National Acad Sciences
Cell proliferation is tightly controlled by inhibitors that block cell cycle progression until
growth signals relieve this inhibition, allowing cells to divide. In several tissues, including the …

The high concentration of progesterone is harmful for endometrial receptivity and decidualization

YX Liang, L Liu, ZY **, XH Liang, YS Fu, XW Gu… - Scientific reports, 2018 - nature.com
Progesterone is required for the establishment and maintenance of mammalian pregnancy
and widely used for conservative treatment of luteal phase deficiency in clinics. However …

The mammalian decidual cell evolved from a cellular stress response

EM Erkenbrack, JD Maziarz, OW Griffith, C Liang… - PLoS …, 2018 - journals.plos.org
Among animal species, cell types vary greatly in terms of number and kind. The number of
cell types found within an organism differs considerably between species, and cell type …

IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice

B Li, YP Yan, YY He, C Liang, MY Li, Y Wang… - Science …, 2023 - science.org
The establishment of pregnancy depends on interactions between the epithelial and stromal
cells of the endometrium that drive the decidual reaction that remodels the stroma and …

BHPF exposure impairs mouse and human decidualization

ZY **, CK Liu, YQ Hong, YX Liang, L Liu… - Environmental Pollution, 2022 - Elsevier
Although BHPF has been widely used in plastic manufacturing as a substitute for BPA,
current evidence suggests that BHPF also causes harmful effects on reproduction. However …

[HTML][HTML] E2F8 is a potential therapeutic target for hepatocellular carcinoma

Y Lv, J **ao, J Liu, F **ng - Journal of Cancer, 2017 - ncbi.nlm.nih.gov
E2F transcriptional factors are widely expressed in a number of tissues and organs,
possessing many regulatory functions related to cellular proliferation, differentiation, DNA …