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Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
DNA damage sensing by the ATM and ATR kinases
In eukaryotic cells, maintenance of genomic stability relies on the coordinated action of a
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …
Platinum resistance in ovarian cancer: role of DNA repair
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially
responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy …
responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy …
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …
apical activator of the DNA damage response in the face of DNA double-strand breaks …
mTOR kinase structure, mechanism and regulation
H Yang, DG Rudge, JD Koos, B Vaidialingam, HJ Yang… - Nature, 2013 - nature.com
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein
kinase, controls cell growth in response to nutrients and growth factors and is frequently …
kinase, controls cell growth in response to nutrients and growth factors and is frequently …
Senescence in post-mitotic cells: a driver of aging?
Significance: Cell senescence was originally defined by an acute loss of replicative capacity
and thus believed to be restricted to proliferation-competent cells. More recently …
and thus believed to be restricted to proliferation-competent cells. More recently …
Mechanisms of ATM activation
The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
DNA mismatch repair and the DNA damage response
Z Li, AH Pearlman, P Hsieh - DNA repair, 2016 - Elsevier
This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …
ATM and ATR signaling at a glance
ABSTRACT ATM and ATR signaling pathways are well conserved throughout evolution and
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …
The Ku heterodimer: function in DNA repair and beyond
Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …