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Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury
Introduction Ischemia–reperfusion injury (IRI) is the inexplicable aggravation of cellular
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …
Neuropeptides: Potential neuroprotective agents in ischemic injury
Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …
Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches
TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …
Mechanistic insight on autophagy modulated molecular pathways in cerebral ischemic injury: from preclinical to clinical perspective
Cerebral ischemia is one of the most devastating brain injuries and a primary cause of
acquired and persistent disability worldwide. Despite ongoing therapeutic interventions at …
acquired and persistent disability worldwide. Despite ongoing therapeutic interventions at …
α-Lipoic acid, an organosulfur biomolecule a novel therapeutic agent for neurodegenerative disorders: an mechanistic perspective
Abstract Lipoic acid (α-LA)(1, 2-dithiolane3-pentanoic acid (C8H14O2S2) is also called
thioctic acid with an oxidized (disulfide, LA) and a reduced (di-thiol: dihydro-lipoic acid …
thioctic acid with an oxidized (disulfide, LA) and a reduced (di-thiol: dihydro-lipoic acid …
Calpain inhibitors as potential therapeutic modulators in neurodegenerative diseases
It is considered a significant challenge to understand the neuronal cell death mechanisms
with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one …
with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one …
Targeting ferroptosis in ischemia/reperfusion renal injury
Renal I/R injury is a severe medical condition contributing to acute kidney injury (AKI),
leading to rapid kidney dysfunction and high mortality rates. It is generally observed during …
leading to rapid kidney dysfunction and high mortality rates. It is generally observed during …
Poly (ADP-ribose) polymerase: an overview of mechanistic approaches and therapeutic opportunities in the management of stroke
Stroke is one of the leading causes of morbidity and mortality accompanied by blood supply
loss to a particular brain area. Several mechanistic approaches such as inhibition of poly …
loss to a particular brain area. Several mechanistic approaches such as inhibition of poly …
Therapeutic implications of phosphorylation-and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration
Neurodegeneration is a condition of the central nervous system (CNS) characterized by loss
of neural structures and function. The most common neurodegenerative disorders (NDDs) …
of neural structures and function. The most common neurodegenerative disorders (NDDs) …
Pharmacological postconditioning by protocatechuic acid attenuates brain injury in ischemia–reperfusion (I/R) mice model: Implications of nuclear factor erythroid-2 …
Abstract Ischemia–reperfusion (I/R) injury often follows cardiovascular aberrations that
predispose the patient to be neurological and cognitive abnormalities. Pharmacological …
predispose the patient to be neurological and cognitive abnormalities. Pharmacological …